Coadministration of glycogen-synthase kinase 3 inhibitor with morphine attenuates chronic morphine-induced analgesic tolerance and withdrawal syndrome.

@article{Liao2014CoadministrationOG,
  title={Coadministration of glycogen-synthase kinase 3 inhibitor with morphine attenuates chronic morphine-induced analgesic tolerance and withdrawal syndrome.},
  author={Wen-Wei Liao and Shih-Ying Tsai and C. Katherine Liao and K Chen and G C Yeh and J Chen and Yeong-Ray Wen},
  journal={Journal of the Chinese Medical Association : JCMA},
  year={2014},
  volume={77 1},
  pages={31-7}
}
BACKGROUND Glycogen-synthase kinase 3 (GSK3) is involved in many signaling pathways and is associated with a host of high-profile pathophysiological states. However, its role in morphine tolerance, especially naloxone-precipitated withdrawal syndrome, has not been well investigated. The present study was undertaken to study the role of GSK3 in chronic… CONTINUE READING