Coadministration of clozapine and fluvoxamine in psychotic patients--clinical experience.

  title={Coadministration of clozapine and fluvoxamine in psychotic patients--clinical experience.},
  author={Claas H Lammers and Michael Deuschle and Harald Weigmann and Sebastian Haertter and Christoph Hiemke and Christoph Heese and Isabella Heuser},
  volume={32 2},
Fluvoxamine (FLUVOX) is an inhibitor of the cytochrome P450 isoenzyme 1 A2 and thereby inhibits clozapine (CLOZ) metabolism. We performed an open clinical study to gather experience in necessary dosages, plasma levels, side effects and clinical efficiency of the coadministration of the two drugs. Eighteen psychotic patients were studied. 50 mg FLUVOX were given throughout the study period, while the CLOZ dosage was increased individually (week 5: 96.9+/-37.2 mg). After 5 weeks the plasma… CONTINUE READING

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