Coadministration of Short‐Term Zolpidem with Sertraline in Healthy Women

@article{Allard1999CoadministrationOS,
  title={Coadministration of Short‐Term Zolpidem with Sertraline in Healthy Women},
  author={Stephane E. Allard and Stephen M. Sainati and Barbara Roth-Schechter},
  journal={The Journal of Clinical Pharmacology},
  year={1999},
  volume={39}
}
This study was undertaken to determine whether there are pharmacokinetic (PK) interactions between zolpidem, a hypnotic, and sertraline, an antidepressant. Twenty‐eight healthy female volunteers received a single dose of zolpidem alone and five consecutive dose(s) of zolpidem 10 mg in the presence of chronic doses (19 days) of sertraline 50 mg. Using HPLC, plasma levels of zolpidem, sertraline, and N‐desmethylsertraline were determined at different times throughout the study and PK parameters… 
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Methods Citations
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Citation Type

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  • 2004
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Few clinically important interactions appear to have been reported in the literature with zaleplon, zolpidem and zopiclone, and the fact that these drugs are newer to the market and have not been as extensively studied as the conventional benzodiazepines may be the reason for this.
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The adverse event profiles of these newer sedative hypnotics, their effects on memory and psychomotor performance, abuse liability concerns and the most recent information about the rare adverse effects that prompted the recent revision to the labelling of drugs in the hypnotic class are reviewed.
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