Coadministration of Short‐Term Zolpidem with Sertraline in Healthy Women

@article{Allard1999CoadministrationOS,
  title={Coadministration of Short‐Term Zolpidem with Sertraline in Healthy Women},
  author={Stephane E. Allard and Stephen M. Sainati and Barbara Roth-Schechter},
  journal={The Journal of Clinical Pharmacology},
  year={1999},
  volume={39}
}
This study was undertaken to determine whether there are pharmacokinetic (PK) interactions between zolpidem, a hypnotic, and sertraline, an antidepressant. Twenty‐eight healthy female volunteers received a single dose of zolpidem alone and five consecutive dose(s) of zolpidem 10 mg in the presence of chronic doses (19 days) of sertraline 50 mg. Using HPLC, plasma levels of zolpidem, sertraline, and N‐desmethylsertraline were determined at different times throughout the study and PK parameters… 
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