Coadministration of P-glycoprotein modulators on loperamide pharmacokinetics and brain distribution.

@article{Montesinos2014CoadministrationOP,
  title={Coadministration of P-glycoprotein modulators on loperamide pharmacokinetics and brain distribution.},
  author={Rita Nieto Montesinos and Brice Moulari and Jessica Gromand and Arnaud B{\'e}duneau and Alf Lamprecht and Yann Pellequer},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2014},
  volume={42 4},
  pages={700-6}
}
The efflux transporter P-glycoprotein, expressed at high levels at the blood-brain barrier, exerts a profound effect on the disposition of various therapeutic compounds in the brain. A rapid and efficient modulation of this efflux transporter could enhance the distribution of its substrates and thereby improve central nervous system pharmacotherapies. This study explored the impact of the intravenous coadministration of two P-glycoprotein modulators, tariquidar and elacridar, on the… CONTINUE READING

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Loperamide misuse and abuse.

Journal of the American Pharmacists Association : JAPhA • 2017

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