Coadministered cannabidiol and clobazam: Preclinical evidence for both pharmacodynamic and pharmacokinetic interactions

@article{Anderson2019CoadministeredCA,
  title={Coadministered cannabidiol and clobazam: Preclinical evidence for both pharmacodynamic and pharmacokinetic interactions},
  author={Lyndsey L. Anderson and Nathan L. Absalom and Sarah V. Abelev and Ivan K Low and Peter T. Doohan and Lewis J Martin and Mary Chebib and Iain S. McGregor and Jonathon C Arnold},
  journal={Epilepsia},
  year={2019},
  volume={60},
  pages={2224 - 2234}
}
Cannabidiol (CBD) has been approved by the US Food and Drug Administration (FDA) to treat intractable childhood epilepsies, such as Dravet syndrome and Lennox‐Gastaut syndrome. However, the intrinsic anticonvulsant activity of CBD has been questioned due to a pharmacokinetic interaction between CBD and a first‐line medication, clobazam. This recognized interaction has led to speculation that the anticonvulsant efficacy of CBD may simply reflect CBD augmenting clobazam exposure. The present… 
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Cannabidiol in conjunction with clobazam: analysis of four randomized controlled trials

To assess the efficacy and safety profile of add‐on cannabidiol (CBD) in patients with Lennox–Gastaut syndrome (LGS) and Dravet syndrome (DS) on clobazam and in the overall population of four…

Commentary on: Coadministered cannabidiol and clobazam: Preclinical evidence for both pharmacodynamic and pharmacokinetic interactions

The authors properly indicate that an increased risk for sudden unexpected death is observed in patients with Dravet syndrome; therefore the aim of their experimental study to evaluate the effectiveness of the combined treatment of cannabidiol with clobazam is fully justified.

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