Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation.

@article{Jin1998CoactivationOT,
  title={Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation.},
  author={Jianguo Jin and Satya P Kunapuli},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 14},
  pages={8070-4}
}
ADP is an important platelet agonist causing shape change and aggregation required for physiological hemostasis. We recently demonstrated the existence of two distinct G protein-coupled ADP receptors on platelets, one coupled to phospholipase C, P2Y1, and the other to inhibition of adenylyl cyclase, P2TAC. In this study, using specific antagonists for these two receptors, we demonstrated that concomitant intracellular signaling from both the P2TAC and P2Y1 receptors is essential for ADP-induced… CONTINUE READING
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Jin and Kunapuli Proc

  • Mills, 76 D.C.B.Thromb.Haemostasis, 835–856. FIG. 5. Model depicting the signal transduction, physiological events mediated by the three ADP receptors on plat Biology
  • Natl. Acad. Sci. USA 95
  • 1998

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