Coactivation of an endogenous progesterone receptor by TIF2 in COS-7 cells.

@article{Hofman2002CoactivationOA,
  title={Coactivation of an endogenous progesterone receptor by TIF2 in COS-7 cells.},
  author={Kurt Hofman and Johannes V Swinnen and G. Arno Verhoeven and Walter Heyns},
  journal={Biochemical and biophysical research communications},
  year={2002},
  volume={295 2},
  pages={
          469-74
        }
}
Transfection experiments, a powerful tool to study the function of steroid hormone receptors and their coregulators, are often performed in COS-7 cells, because of high transfection efficiencies and expression levels. Here we report on the presence in COS-7 cells of an endogenous steroid hormone receptor, which is highly responsive to progesterone and the synthetic steroids R1881 and ORG2058, but not to 5 alpha-DHT. A 10-fold excess of the progesterone antagonist RU486 abolishes the stimulation… CONTINUE READING
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