Coactivation of G Protein Signaling by Cell-Surface Receptors and an Intracellular Exchange Factor

@article{Lee2008CoactivationOG,
  title={Coactivation of G Protein Signaling by Cell-Surface Receptors and an Intracellular Exchange Factor},
  author={Michael J. Y. Lee and Henrik G. Dohlman},
  journal={Current Biology},
  year={2008},
  volume={18},
  pages={211-215}
}
G protein-coupled receptors (GPCRs) mediate responses to a broad range of chemical and environmental signals. In yeast, a pheromone-binding GPCR triggers events leading to the fusion of haploid cells. In general, GPCRs function as guanine-nucleotide exchange factors (GEFs); upon agonist binding, the receptor induces a conformational change in the G protein alpha subunit, resulting in exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and in signal initiation. Signaling is… CONTINUE READING
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