Coactivation of AKT and β-catenin in mice rapidly induces formation of lipogenic liver tumors.

@article{Stauffer2011CoactivationOA,
  title={Coactivation of AKT and β-catenin in mice rapidly induces formation of lipogenic liver tumors.},
  author={Jimmy K. Stauffer and Anthony J. Scarzello and Jesper B Andersen and Rachel De Kluyver and Timothy C. Back and Jonathan M. Weiss and Snorri Thorgeirsson and Robert H. Wiltrout},
  journal={Cancer research},
  year={2011},
  volume={71 7},
  pages={2718-27}
}
Obesity is a risk factor for development of certain cancers but the basis for this risk is unclear. In this study, we developed a novel mouse model that demonstrates directly how lipogenic phenotypes commonly associated with diet-induced metabolic syndromes can influence hepatic cancer development. Activated AKT and β-catenin (AKT/CAT) genes were hydrodynamically codelivered using the Sleeping Beauty transposon to initiate liver tumorigenesis. AKT/CAT and MET/CAT combination induced microscopic… CONTINUE READING
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