CoREST: a functional corepressor required for regulation of neural-specific gene expression.

@article{Andrs1999CoRESTAF,
  title={CoREST: a functional corepressor required for regulation of neural-specific gene expression.},
  author={Mar{\'i}a Estela Andr{\'e}s and Corinna Burger and M J Peral-Rubio and Elena Battaglioli and Mark E. Anderson and Janelle Grimes and Julia E. Dallman and Nurit Ballas and Gail Mandel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 17},
  pages={9873-8}
}
Several genes encoding proteins critical to the neuronal phenotype, such as the brain type II sodium channel gene, are expressed to high levels only in neurons. This cell specificity is due, in part, to long-term repression in nonneural cells mediated by the repressor protein REST/NRSF (RE1 silencing transcription factor/neural-restrictive silencing factor). We show here that CoREST, a newly identified human protein, functions as a corepressor for REST. A single zinc finger motif in REST is… CONTINUE READING
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