CoQ10 Deficiency May Indicate Mitochondrial Dysfunction in Cr(VI) Toxicity

  title={CoQ10 Deficiency May Indicate Mitochondrial Dysfunction in Cr(VI) Toxicity},
  author={Xiali Zhong and Xing Yi and Rita de C{\'a}ssia da Silveira e S{\'a} and Yujing Zhang and Kaihua Liu and Fang Xiao and Caigao Zhong},
  booktitle={International journal of molecular sciences},
To investigate the toxic mechanism of hexavalent chromium Cr(VI) and search for an antidote for Cr(VI)-induced cytotoxicity, a study of mitochondrial dysfunction induced by Cr(VI) and cell survival by recovering mitochondrial function was performed. In the present study, we found that the gene expression of electron transfer flavoprotein dehydrogenase (ETFDH) was strongly downregulated by Cr(VI) exposure. The levels of coenzyme 10 (CoQ10) and mitochondrial biogenesis presented by mitochondrial… CONTINUE READING
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Biosynthesis of coenzyme Q in eukaryotes.

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