CoMFA and CoMSIA of diverse pyrrolidine analogues as dipeptidyl peptidase IV inhibitors: active site requirements

@article{Murugesan2010CoMFAAC,
  title={CoMFA and CoMSIA of diverse pyrrolidine analogues as dipeptidyl peptidase IV inhibitors: active site requirements},
  author={Vanangamudi Murugesan and Nidhi Sethi and Yenamandra S. Prabhakar and Seturam B Katti},
  journal={Molecular Diversity},
  year={2010},
  volume={15},
  pages={457-466}
}
The inhibition of dipeptidyl peptidase IV (DPP-IV) has emerged as an attractive target in the treatment of type 2 diabetes. In view of this development, a critical analysis of structural requirements of the DPP-IV inhibitors is envisioned to identify the significant features toward design of selective inhibitors. The comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) contour plots of pyrrolidine based analogues are used to analyze the… CONTINUE READING

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