CoFold: an RNA secondary structure prediction method that takes co-transcriptional folding into account

@inproceedings{Proctor2013CoFoldAR,
  title={CoFold: an RNA secondary structure prediction method that takes co-transcriptional folding into account},
  author={Jeff R. Proctor and Irmtraud M. Meyer},
  booktitle={Nucleic acids research},
  year={2013}
}
Existing state-of-the-art methods that take a single RNA sequence and predict the corresponding RNA secondary structure are thermodynamic methods. These aim to predict the most stable RNA structure. There exists by now ample experimental and theoretical evidence that the process of structure formation matters and that sequences in vivo fold while they are being transcribed. None of the thermodynamic methods, however, consider the process of structure formation. Here, we present a conceptually… CONTINUE READING
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