CoBi: Pattern Based Co-Regulated Biclustering of Gene Expression Data

  title={CoBi: Pattern Based Co-Regulated Biclustering of Gene Expression Data},
  author={Swarup Roy and Dhruba Kumar Bhattacharyya and Jugal K. Kalita},
  journal={Pattern Recognition Letters},
Co-regulation is a common phenomenon in gene expression. Finding positively and negatively co-regulated gene clusters from gene expression data is a real need. Existing techniques based on global similarity are unable to detect true upand down-regulated gene clusters. This paper presents an expression pattern based biclustering technique, CoBi, for grouping both positively and negatively regulated genes from microarray expression data. Regulation pattern and similarity in degree of fluctuation… CONTINUE READING
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