Co-variation in frequency and severity of cardiovascular and skeletal defects in Sprague-Dawley rats after maternal administration of dimethadione, the N-demethylated metabolite of trimethadione.

@article{Weston2011CovariationIF,
  title={Co-variation in frequency and severity of cardiovascular and skeletal defects in Sprague-Dawley rats after maternal administration of dimethadione, the N-demethylated metabolite of trimethadione.},
  author={Andrea D Weston and Nigel Brown and Terence R. S. Ozolin{\vs}},
  journal={Birth defects research. Part B, Developmental and reproductive toxicology},
  year={2011},
  volume={92 3},
  pages={206-15}
}
BACKGROUND The anticonvulsant trimethadione is a potent inducer of ventricular septation defects, both clinically and in rodents. Teratogenicity requires its N-demethylation to dimethadione, the proximate teratogen. It was previously demonstrated trimethadione only induced membranous ventricular septation defects in rat (Fleeman et al., 2004), and our present goal is to determine whether direct administration of dimethadione increases the incidence and severity of septation defects. METHODS… CONTINUE READING

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