Co-treatment of dichloroacetate, omeprazole and tamoxifen exhibited synergistically antiproliferative effect on malignant tumors: in vivo experiments and a case report.

@article{Ishiguro2012CotreatmentOD,
  title={Co-treatment of dichloroacetate, omeprazole and tamoxifen exhibited synergistically antiproliferative effect on malignant tumors: in vivo experiments and a case report.},
  author={Tatsuaki Ishiguro and Ryumei Ishiguro and Miyu Ishiguro and Sayuri Iwai},
  journal={Hepato-gastroenterology},
  year={2012},
  volume={59 116},
  pages={994-6}
}
BACKGROUND/AIMS Omeprazole (OPZ) and tamoxifen (TAM) strengthen the effects of anticancer drugs and dichloroacetate (DCA) inhibits tumor growth. This study assesses the synergistic effects of these drugs. METHODOLOGY HT1080 human fibrosarcoma cells and WI-38 human fibroblasts were used as test and control cells, respectively. DCA, OPZ and TAM alone or in combination were applied and cells were counted after a one week culture. The combination of these drugs was prescribed to a… CONTINUE READING
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