Co-treatment of PTH with osteoprotegerin or alendronate increases its anabolic effect on the skeleton of oophorectomized mice.

@article{Samadfam2007CotreatmentOP,
  title={Co-treatment of PTH with osteoprotegerin or alendronate increases its anabolic effect on the skeleton of oophorectomized mice.},
  author={Rana Samadfam and Qingwen Xia and David Goltzman},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2007},
  volume={22 1},
  pages={55-63}
}
UNLABELLED We examined the effects of 60 days of co-treatment of PTH with either OPG or alendronate in oophorectomized mice. Compared with PTH alone, co-treatment of PTH with either of these two mechanistically distinct anti-catabolics improved bone volume, mechanical strength, and appendicular and axial mineralization and prolonged the beneficial effect of PTH on BMD. INTRODUCTION Conflicting evidence exists as to whether the anabolic effect of PTH is inhibited by the action of anti… CONTINUE READING