Co-treating with arecoline and 4-nitroquinoline 1-oxide to establish a mouse model mimicking oral tumorigenesis.

@article{Chang2010CotreatingWA,
  title={Co-treating with arecoline and 4-nitroquinoline 1-oxide to establish a mouse model mimicking oral tumorigenesis.},
  author={Nai-Wen Chang and Ren-Jeng Pei and Hsien-Chang Tseng and K L Yeh and H M Chan and Miau-Rong Lee and Chingju Lin and Wen-Tsong Hsieh and Ming-Ching Kao and Ming-Hsui Tsai and Chin-Fen Lin},
  journal={Chemico-biological interactions},
  year={2010},
  volume={183 1},
  pages={231-7}
}
The aim of this study was to establish an effective mouse model of oral cancer and to use this model to identify potential markers of oral tumor progression. C57BL/6JNarl mice were treated with arecoline, 4-nitroquinoline 1-oxide (4-NQO), or both arecoline and 4-NQO in high and low doses for 8 weeks to induce oral tumor. The induced oral lesions were… CONTINUE READING