Co-translational protein targeting by the signal recognition particle.

  title={Co-translational protein targeting by the signal recognition particle.},
  author={Shu-Ou Shan and Peter J. Walter},
  journal={FEBS letters},
  volume={579 4},
The signal recognition particle (SRP) mediates the co-translational targeting of nascent proteins to the eukaryotic endoplasmic reticulum membrane, or the bacterial plasma membrane. During this process, two GTPases, one in the SRP and one in the SRP receptor (SR), form a complex in which both proteins reciprocally activate the GTPase reaction of one another. The recent crystal structures of the T. aquaticus SRP.SR complex show that the two GTPases associate via an unusually extensive and highly… CONTINUE READING