Co-transcriptional splicing of pre-messenger RNAs: considerations for the mechanism of alternative splicing.

@article{Goldstrohm2001CotranscriptionalSO,
  title={Co-transcriptional splicing of pre-messenger RNAs: considerations for the mechanism of alternative splicing.},
  author={Aaron C Goldstrohm and Arno L. Greenleaf and Mariano A. Garcia-Blanco},
  journal={Gene},
  year={2001},
  volume={277 1-2},
  pages={31-47}
}
Nascent transcripts are the true substrates for many splicing events in mammalian cells. In this review we discuss transcription, splicing, and alternative splicing in the context of co-transcriptional processing of pre-mRNA. The realization that splicing occurs co-transcriptionally requires two important considerations: First, the cis-acting elements in the splicing substrate are synthesized at different times in a 5' to 3' direction. This dynamic view of the substrate implies that in a 100 kb… CONTINUE READING

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