Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells

@inproceedings{Mancini2014CotargetingTI,
  title={Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells},
  author={Maria Mancini and Marzia B Gariboldi and Elisa Taiana and Maria Chiara Bonzi and Ilaria Craparotta and Marina Tochetti Pagin and Elena Monti},
  booktitle={British Journal of Cancer},
  year={2014}
}
Background:Metastatic triple-negative breast cancer is mostly incurable, due to lack of suitable drug targets. The insulin-like growth factor (IGF) system could provide such a target, and IGF-1 receptor (IGF-1R)-directed agents are already available, but seem unable to control all the complexities of the system, including crosstalk with hypoxia-inducible pathways.Methods:Migration of triple-negative MDA-231 breast cancer cells and its modulation by IGFs, the IGF-1R inhibitor NVP-AEW541 and the… CONTINUE READING

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