Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

@article{Croft2003CostimulatoryMO,
  title={Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?},
  author={Michael Croft},
  journal={Nature Reviews Immunology},
  year={2003},
  volume={3},
  pages={609-620}
}
  • M. Croft
  • Published 1 August 2003
  • Biology, Medicine
  • Nature Reviews Immunology
Interactions between co-stimulatory ligands and their receptors are crucial for the activation of T cells, the prevention of tolerance and the development of T-cell immunity. It is now evident that members of the immunoglobulin-like CD28–B7 co-stimulatory family cannot fully account for an effective long-lasting T-cell response or the generation of memory T cells. Several members of the tumour-necrosis factor receptor (TNFR) superfamily — OX40, 4-1BB, CD27, CD30 and HVEM (herpes-virus entry… 

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