Co-stimulatory blockade with belatacept in kidney transplantation.

  title={Co-stimulatory blockade with belatacept in kidney transplantation.},
  author={Bhavna Chopra and Kalathil K Sureshkumar},
  journal={Expert opinion on biological therapy},
  volume={14 5},
Calcineurin inhibitors (CNIs) are the cornerstone of immunosuppression after transplantation but can exert negative effects on chronic allograft function and metabolic profile. Belatacept, a selective co-stimulation blocker of T cells, is the first biologic agent approved for maintenance immunosuppression in kidney transplantation. Studies reveal better preservation of glomerular filtration rate and improved metabolic end points with belatacept when compared to CNIs. Increased incidence of… CONTINUE READING
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