Co-stimulation of T cells with CD2 augments TCR-CD3-mediated activation of protein tyrosine kinase p72syk, resulting in increased tyrosine phosphorylation of adapter proteins, Shc and Cbl.

@article{Umehara1998CostimulationOT,
  title={Co-stimulation of T cells with CD2 augments TCR-CD3-mediated activation of protein tyrosine kinase p72syk, resulting in increased tyrosine phosphorylation of adapter proteins, Shc and Cbl.},
  author={Hisanori Umehara and Ji Ying Huang and Takeshi Kono and Fazal Haq Tabassam and Toshiro Okazaki and Shunichi Gouda and Yukio Nagano and Eda T. Bloom and Naochika Domae},
  journal={International immunology},
  year={1998},
  volume={10 6},
  pages={833-45}
}
Complete T cell activation requires not only the first signal via TCR-CD3 engagement, but also a co-stimulatory signal through accessory receptors such as CD2, LFA-1 and CD28. However, the pathway of co-stimulatory signaling through accessory receptors is incompletely understood. We report here that CD2 provides a co-stimulus for activation of CD3-mediated syk/ZAP-70 family kinase, p72Syk (Syk), in Jurkat T cells. Although cross-linking of CD2 alone or any combination of CD2 with LFA-1alpha… CONTINUE READING
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