Co-regulation proteomics reveals substrates and mechanisms of APC/C-dependent degradation.

@article{Singh2014CoregulationPR,
  title={Co-regulation proteomics reveals substrates and mechanisms of APC/C-dependent degradation.},
  author={Sasha A Singh and Dominic Winter and Marc Kirchner and Ruchi Chauhan and Saima Ahmed and Nurhan Ozlu and Amit Tzur and Judith A.J. Steen and Hanno Steen},
  journal={The EMBO journal},
  year={2014},
  volume={33 4},
  pages={385-99}
}
Using multiplexed quantitative proteomics, we analyzed cell cycle-dependent changes of the human proteome. We identified >4,400 proteins, each with a six-point abundance profile across the cell cycle. Hypothesizing that proteins with similar abundance profiles are co-regulated, we clustered the proteins with abundance profiles most similar to known Anaphase-Promoting Complex/Cyclosome (APC/C) substrates to identify additional putative APC/C substrates. This protein profile similarity screening… CONTINUE READING

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