Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.

@article{Navarre2005CoregulationOS,
  title={Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.},
  author={William Wiley Navarre and Thomas A Halsey and Don Walthers and Jonathan Frye and Michael McClelland and Jennifer L Potter and Linda J Kenney and John S Gunn and Ferric C Fang and Stephen James Libby},
  journal={Molecular microbiology},
  year={2005},
  volume={56 2},
  pages={492-508}
}
Analysis of the transcriptome of slyA mutant Salmonella enterica serovar Typhimurium revealed that many SlyA-dependent genes, including pagC, pagD, ugtL, mig-14, virK, phoN, pgtE, pipB2, sopD2, pagJ and pagK, are also controlled by the PhoP/PhoQ regulatory system. Many SlyA- and PhoP/PhoQ-co-regulated genes have functions associated with the bacterial envelope, and some have been directly implicated in virulence and resistance to antimicrobial peptides. Purified His-tagged SlyA binds to the… CONTINUE READING
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