Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers.

@article{Aberg2008CoregulationAI,
  title={Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers.},
  author={Karin M Aberg and M W-L Man and Richard L Gallo and Tomas Ganz and Debra C Crumrine and Barbara E. Brown and Eung Ho Choi and Dong-Kun Kim and Jens Michael Schr{\"o}der and Kenneth R. Feingold and Peter M Elias},
  journal={The Journal of investigative dermatology},
  year={2008},
  volume={128 4},
  pages={917-25}
}
Human epidermis elaborates two small cationic, highly hydrophobic antimicrobial peptides (AMP), beta-defensin 2 (hBD2), and the carboxypeptide cleavage product of human cathelicidin (hCAP18), LL-37, which are co-packaged along with lipids within epidermal lamellar bodies (LBs) before their secretion. Because of their colocalization, we hypothesized that AMP and barrier lipid production could be coregulated by altered permeability barrier requirements. mRNA and immunostainable protein levels for… CONTINUE READING
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