Co-receptor usage of BOB/GPR15 in addition to CCR5 has no significant effect on replication of simian immunodeficiency virus in vivo.

@article{Phlmann1999CoreceptorUO,
  title={Co-receptor usage of BOB/GPR15 in addition to CCR5 has no significant effect on replication of simian immunodeficiency virus in vivo.},
  author={Stefan P{\"o}hlmann and Nicole Stolte and Jan M{\"u}nch and Peter J F Ten Haaft and Jonathan Luke Heeney and Christiane Stahl-Hennig and Frank Kirchhoff},
  journal={The Journal of infectious diseases},
  year={1999},
  volume={180 5},
  pages={1494-502}
}
Human immunodeficiency virus type 2 (HIV-2) and the closely related simian immunodeficiency viruses (SIVs) frequently use the orphan receptor BOB/GPR15 in addition to the chemokine receptor CCR5 for efficient entry and replication. However, the role of BOB/GPR15 in replication and pathogenesis of HIV-2 and SIV in vivo is unclear. This study shows that a single amino acid substitution in the V3 loop of the pathogenic SIVmac239 clone, 321P-->S, impaired the ability to use BOB/GPR15 for entry and… CONTINUE READING

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