Co-production, multiplied: Enactments of sex as a biological variable in US biomedicine

@article{Pape2021CoproductionME,
  title={Co-production, multiplied: Enactments of sex as a biological variable in US biomedicine},
  author={Madeleine Pape},
  journal={Social Studies of Science},
  year={2021},
  volume={51},
  pages={339 - 363}
}
  • Madeleine Pape
  • Published 24 January 2021
  • Sociology
  • Social Studies of Science
In 2016 the US National Institutes of Health introduced a policy mandating consideration of Sex as a Biological Variable (SABV) in preclinical research. In this article, I ask what, precisely, is meant by the designation of sex as a ‘biological variable’, and how has its inclusion come to take the form of a policy mandate? Given the well documented complexity of ‘sex’ and the degree to which it is politically and scientifically contested, its enactment via policy as a biological variable is not… 

Figures from this paper

Lost in translation? Beyond sex as a biological variable in animal research

  • Madeleine Pape
  • Sociology
    Health sociology review : the journal of the Health Section of the Australian Sociological Association
  • 2021
TLDR
A feminist posthumanist account of biomedical policymaking as a material-discursive intervention that shapes the emergence of phenomena in the scientific laboratory is developed, showing how laboratory animals reveal the context-specific character of sex, its multiplicity and elusiveness as a so-called biological variable.

Cultivated co-production: Sexual health, human rights, and the revision of the ICD

  • S. Epstein
  • Political Science
    Social studies of science
  • 2021
TLDR
The creation of a new chapter on 'sexual health' in the recent revision of the International Classification of Diseases offers a case of what might be termed 'cultivated co-production', and indicates awareness of the need to manage the contested nature of gender and sexuality at a transnational level.

Sins of inquiry: How to criticize scientific pursuits.

References

SHOWING 1-10 OF 118 REFERENCES

Studying both sexes: a guiding principle for biomedicine

  • J. Clayton
  • Medicine, Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2016
TLDR
The rationale behind the SABV policy component is described and the practice of studying both sexes in preclinical research will expand the currently incomplete knowledge base that plays a critical role in informing the development of sex‐and gender‐appropriate medical care for women and men.

Complexities of Addressing Sex in Cell Culture Research

  • S. Ritz
  • Sociology
    Signs: Journal of Women in Culture and Society
  • 2017
The documentation of gendered disparities in health has led to calls for scientists across the spectrum of biomedical research to attend to sex and gender considerations in their work. In basic

First steps for integrating sex and gender considerations into basic experimental biomedical research

  • S. RitzD. Antle D. Mergler
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2014
TLDR
A number of strategies are suggested that allow basic experimental researchers to feasibly and meaningfully take sex and gender into account in their work and not undermine their ability to pursue their fundamental scientific interests.

Why are sex and gender important to basic physiology and translational and individualized medicine?

  • V. Miller
  • Medicine
    American journal of physiology. Heart and circulatory physiology
  • 2014
TLDR
Evidence showing how sex and gender interact with each other to influence etiology, presentation of disease, and treatment outcomes is reviewed and evidence for advancing personalized medicine is reviewed.

Considering Sex as a Biological Variable in Biomedical Research

TLDR
This commentary serves to provide some perspective about exactly how to study males and females, particularly in basic research.

Twenty years and still counting: including women as participants and studying sex and gender in biomedical research

TLDR
It has been 20 years since the first requirements to include women as well as men in clinical trials and analyze results by sex were mandated by a U.S. federal law, yet not nearly enough progress has been made, prompting specific instrumental recommendations for how to include the study of sex and gender in research.

NIH initiative to balance sex of animals in preclinical studies: generative questions to guide policy, implementation, and metrics

In May of 2014, the NIH Director together with the Director of the Office of Research on Women’s Health announced plans to take a multi-dimensional approach to address the over reliance on male cells

Recommendations concerning the new U.S. National Institutes of Health initiative to balance the sex of cells and animals in preclinical research

  • K. SandbergJ. Umans
  • Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2015
TLDR
The resulting consensus presented herein includes input from researchers not only from diverse disciplines of basic and translational science including biology, cell and molecular biology, biochemistry, physiology, pharmacology, neuroscience, cardiology, endocrinology, nephrology, psychiatry, and obstetrics and gynecology, but also from recognized experts in publishing, industry, advocacy, science policy, clinical medicine, and population health.

Sex/gender influences on the nervous system: Basic steps toward clinical progress

TLDR
A Commentary highlighting the progress that sex‐based data and research have made in neuroscience and the complexities that research has revealed thus far and the expansion of knowledge in preclinical neuroscience that integrates the study of both sexes will have a significant role in informing clinical trial design.
...