Co-precipitation of amoxicillin and ethyl cellulose microparticles by supercritical antisolvent process

@inproceedings{Montes2011CoprecipitationOA,
  title={Co-precipitation of amoxicillin and ethyl cellulose microparticles by supercritical antisolvent process},
  author={Alejandro Oviedo Montes and Mar{\'i}a Dolores Gordillo Gordillo and Clara Pereyra and E. J. Mart{\'i}nez de la Ossa},
  year={2011}
}
Microparticles of ethyl cellulose (EC) and amoxicillin (AMC) have been precipitated by a supercritical antisolvent process (SAS) using CO2 as the antisolvent and a mixture of dichloromethane (DCM) and dimethyl sulfoxide (DMSO) as solvents. Combinations of three temperatures (308, 323 and 333 K) and four pressures (100, 150, 200 and 250 bar) were assessed in the vessel and the rest of the variables were held constant (i.e. CO2 flow rate, sample flow rate, washing time, nozzle diameter and the… CONTINUE READING

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