Co-populated conformational ensembles of beta2-microglobulin uncovered quantitatively by electrospray ionization mass spectrometry.

@article{Borysik2004CopopulatedCE,
  title={Co-populated conformational ensembles of beta2-microglobulin uncovered quantitatively by electrospray ionization mass spectrometry.},
  author={Antoni J H Borysik and Sheena E Radford and Alison E Ashcroft},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 26},
  pages={27069-77}
}
Ordered assembly of monomeric human beta(2)-microglobulin (beta(2)m) into amyloid fibrils is associated with the disorder hemodialysis-related amyloidosis. Previously, we have shown that under acidic conditions (pH <5.0 at 37 degrees C), wild-type beta(2)m assembles spontaneously into fibrils with different morphologies. Under these conditions, beta(2)m populates a number of different conformational states in vitro. However, this equilibrium mixture of conformationally different species is… CONTINUE READING

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