Co-overexpression of HER2/HER3 is a predictor of impaired survival in breast cancer patients.

  title={Co-overexpression of HER2/HER3 is a predictor of impaired survival in breast cancer patients.},
  author={Anna Sophie Berghoff and Rupert Bartsch and Matthias Preusser and Gerda Ricken and Guenther G. Steger and Zsuzsanna Bago-Horvath and Margareta Rudas and Berthold Streubel and Peter Christian Dubsky and Michael Gnant and Florian Fitzal and Christoph Carl Zielinski and Peter Birner},
  volume={23 5},
BACKGROUND Recently, HER3-expression was postulated as independent risk factor for metastatic spread. Therefore, we investigated the role of HER3 expression as prognostic marker in metastatic breast cancer patients. METHODS Patients of different breast cancer subtypes diagnosed with metastatic disease (visceral and/or brain metastases) were identified from a breast cancer database. Tissue samples of the respective primary tumors were retrieved, and immunohistochemical staining for estrogen… CONTINUE READING
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