Co-ordination of quorum-sensing regulation in Rhizobium leguminosarum by induction of an anti-repressor.

@article{Frederix2011CoordinationOQ,
  title={Co-ordination of quorum-sensing regulation in Rhizobium leguminosarum by induction of an anti-repressor.},
  author={Marijke Frederix and Anne Edwards and Craig McAnulla and J Allan Downie},
  journal={Molecular microbiology},
  year={2011},
  volume={81 4},
  pages={
          994-1007
        }
}
Analysis of quorum-sensing (QS) regulation in Rhizobium leguminosarum revealed an unusual type of gene regulation that relies on the population density-dependent accumulation of an anti-repressor. The cinS gene, which is co-transcribed with the N-acyl-homoserine-lactone synthase gene cinI, is required to fully induce rhiR and raiR, whose products, together with their partner AHL synthases, regulate other genes in a QS-regulated hierarchy. Purified CinS bound to the R. leguminosarum… CONTINUE READING
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