Co-ordinated expression of 5-HT2C receptors with the NCX1 Na+/Ca2+ exchanger in histaminergic neurones.

@article{Sergeeva2003CoordinatedEO,
  title={Co-ordinated expression of 5-HT2C receptors with the NCX1 Na+/Ca2+ exchanger in histaminergic neurones.},
  author={Olga A. Sergeeva and Bettina T. Amberger and Krister S. Eriksson and Annette Scherer and Helmut L. Haas},
  journal={Journal of neurochemistry},
  year={2003},
  volume={87 3},
  pages={657-64}
}
The different roles of Na+/Ca2+ (NCX) exchangers and Na+/Ca2+/K+ (NCKX) exchangers in regulation of the ionic homeostasis in neurones are poorly understood. We have previously shown that serotonin excites histaminergic tuberomamillary (TM) neurones by activation of 5-HT2C-receptors and Na+/Ca2+ exchange. With the help of single-cell RT-PCR (sc-RT-PCR) we have now determined the coexpression pattern of different subtypes of NCX and NCKX with serotonin receptors. The majority of TM neurones… CONTINUE READING