Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart.

@article{He2011CooccupancyBM,
  title={Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart.},
  author={Aibin He and Sek Won Kong and Qing Ma and William T. Pu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 14},
  pages={
          5632-7
        }
}
Identification of genomic regions that control tissue-specific gene expression is currently problematic. ChIP and high-throughput sequencing (ChIP-seq) of enhancer-associated proteins such as p300 identifies some but not all enhancers active in a tissue. Here we show that co-occupancy of a chromatin region by multiple transcription factors (TFs) identifies a distinct set of enhancers. GATA-binding protein 4 (GATA4), NK2 transcription factor-related, locus 5 (NKX2-5), T-box 5 (TBX5), serum… CONTINUE READING

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