Co-mutated pathways analysis highlights the coordination mechanism in glioblastoma multiforme.

  title={Co-mutated pathways analysis highlights the coordination mechanism in glioblastoma multiforme.},
  author={Bo Wei and L. Wang and X D Zhao and Y. L. Jin and Daliang Kong and Guozhang Hu and Z. Sun},
  volume={61 4},
The mutation of cancer represents a high heterogeneity characteristic, setting a big obstacle in the mechanism study of it. In this study, we explored the distributions of mutated genes in pathways in glioblastoma multiforme (GBM), and constructed networks of co-mutated pathway pairs under the false discovery rate (FDR) control. By comparing the mutation frequencies, a total of 50 mutated genes were screened with the frequency > 3, and TP53, PTEN, and EGFR were the top 3 genes. By KEGG… 
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