Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation.

@article{Saleem2002ColocalizationON,
  title={Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation.},
  author={Moin Saleem and Lan Ni and Ian R. Witherden and K. Tryggvason and Vesa Ruotsalainen and Peter H. Mundel and Peter William Mathieson},
  journal={The American journal of pathology},
  year={2002},
  volume={161 4},
  pages={1459-66}
}
The discovery of the genes for nephrin and podocin, which are mutated in two types of congenital nephrotic syndrome, was pivotal in establishing the podocyte as the central component of the glomerular filtration barrier. In vivo the proteins have been localized to the podocyte slit diaphragm, and there is recent evidence for interaction between the two via the adapter molecule CD2AP. We describe in a human podocyte cell line, the subcellular distribution of nephrin, podocins, and CD2AP and… CONTINUE READING
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