Co-localization of midbrain projections, progestin receptors, and mating-induced fos in the hypothalamic ventromedial nucleus of the female rat

@article{FlanaganCato2006ColocalizationOM,
  title={Co-localization of midbrain projections, progestin receptors, and mating-induced fos in the hypothalamic ventromedial nucleus of the female rat},
  author={Loretta M. Flanagan-Cato and Beney J. Lee and Lyngine H. Calizo},
  journal={Hormones and Behavior},
  year={2006},
  volume={50},
  pages={52-60}
}
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36 Citations
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36 Citations

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Effects of ovariectomy on inputs from the medial preoptic area to the ventromedial nucleus of the hypothalamus of young adult rats
TLDR
The data show the changes in the organization of the connections observed in the OVX adult rats that displayed a reduced axonal length for the MPN fibres reaching the VMHvl, suggesting that peripubertal ovarian hormones are relevant to the organizations of MPN connections with structures involved in the promotion of female sexual behaviour.
Induction and subcellular redistribution of progesterone receptor A and B by tamoxifen in the hypothalamic ventromedial neurons of young adult female Wistar rats
Estrogen receptor alpha is required in GABAergic, but not glutamatergic, neurons to masculinize the brain
TLDR
It is demonstrated that ERα masculinizes GABAergic neurons that gate the display of male-typical behaviors.
The nucleus para-retroambiguus: A new group of estrogen receptive cells in the caudal ventrolateral medulla of the female golden hamster
Estrogen receptors α and β have different roles in the induction and trafficking of progesterone receptors in hypothalamic ventromedial neurons
TLDR
The findings reveal that individual and simultaneous activation of ERα and ERβ have different effects on the levels and subcellular location of PRs in VMNvl neurons.
Role of plasma membrane estrogen receptors in mediating the estrogen induction of progesterone receptors in hypothalamic ventromedial neurons
TLDR
The results showed that the administration of E2BSA alone increases the number of PR‐immunoreactive neurons and the expression level of PR protein to values similar to those resulting from E2 administration, providing the first evidence that membrane‐initiated E2 stimulation is able to induce and to potentiate the genomic activation of PR expression in the VMN.
Androgen receptors are required for full masculinization of the ventromedial hypothalamus (VMH) in rats
Role of estrogen receptor α and β in the induction of progesterone receptors in hypothalamic ventromedial neurons
Altered position of cell bodies and fibers in the ventromedial region in SF-1 knockout mice
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References

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Hormonal-neural integration in the female rat ventromedial hypothalamus: triple labeling for estrogen receptor-alpha, retrograde tract tracing from the periaqueductal gray, and mating-induced Fos expression.
TLDR
The results suggest that mating activates several distinct VMH neuron types, however, ERalpha-IR neurons are activated to a greater extent compared with the PAG-projecting neurons.
Projections from ventrolateral hypothalamic neurons containing progesterone receptors and somatostatin to the midbrain central gray in the female guinea pig
Abstract. The goal of this study was to determine, by combining retrograde fluorescent tract tracing with double immunocytochemistry, whether neurons immunoreactive (IR) for both progesterone…
Induction of FOS immunoreactivity in oxytocin neurons after sexual activity in female rats.
TLDR
The results are consistent with the hypothesis that endogenous OT is involved in female sexual behavior, and suggest that the source of oxytocinergic innervation to the Oxytocin receptors in the VMN may be neurons in the PVN.
Functionally-defined compartments of the lordosis neural circuit in the ventromedial hypothalamus in female rats.
TLDR
The results suggest that oxytocin may directly influence these lordosis-relevant VMH projection neurons, whereas estrogen may have transsynaptic effects.
Divergent axon collaterals originate in the estrogen receptive ventromedial nucleus of hypothalamus in the rat.
TLDR
Some of the VMHvl neurons that communicate a facilitatory signal to the PAG may also act to stimulate lordosis through a feedback suppression of the net inhibition formed by efferent signals from the forebrain.
Estradiol and progesterone influence the response of ventromedial hypothalamic neurons to tactile stimuli associated with female reproduction
Projections from Ventrolateral Hypothalamic Neurons Containing Progestin Receptor‐ and Substance P‐Immunoreactivity to Specific Forebrain and Midbrain Areas in Female Guinea Pigs
TLDR
Many neurons within the ventrolateral hypothalamus in guinea pigs contain estrogen‐induced progestin receptors as well as substance P and may prove to be components of the neural circuitry underlying a variety of functions influenced by gonadal steroid hormones and substance P, such as female sexual behavior, salt intake, nociception and aggression.
A subset of progesterone target neurons have axonal projections to the midbrain
Dilute estradiol implants and progestin receptor induction in the ventromedial nucleus of the hypothalamus: correlation with receptive behavior in female rats.
TLDR
The findings suggest that local estrogenic stimulation of target cells in the VMN is capable of both priming the estrous response and induction of P receptors, and whether these two effects are causally related awaits future study.
Progesterone treatment increases Fos-immunoreactivity within some progestin receptor-containing neurons in localized regions of female rat forebrain
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