Co-localization of TSC1 and TSC2 gene products in tubers of patients with tuberous sclerosis.

@article{Johnson1999ColocalizationOT,
  title={Co-localization of TSC1 and TSC2 gene products in tubers of patients with tuberous sclerosis.},
  author={Mark W. Johnson and Jessica K. Emelin and Sun Hwa Park and H V Vinters},
  journal={Brain pathology},
  year={1999},
  volume={9 1},
  pages={45-54}
}
Two genes, mutations in which result in the phenotype of tuberous sclerosis (TSC), have recently been cloned. TSC2 on chromosome 16p13.3 encodes the protein tuberin, which appears to have growth regulating properties. TSC1 on chromosome 9q34 encodes hamartin which, as yet, has no specified cellular functions. Polyclonal antibodies were raised to synthetic peptides representing portions of tuberin and hamartin and used in immunoblots and immunohistochemical studies to localize the proteins in… CONTINUE READING
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