Co-localization of GABAA receptors and benzodiazepine receptors in the brain shown by monoclonal antibodies

@article{Schoch1985ColocalizationOG,
  title={Co-localization of GABAA receptors and benzodiazepine receptors in the brain shown by monoclonal antibodies},
  author={P. Schoch and J. Richards and P. H{\"a}ring and B. Tak{\'a}cs and C. St{\"a}hli and T. Staehelin and W. Haefely and H. M{\"o}hler},
  journal={Nature},
  year={1985},
  volume={314},
  pages={168-171}
}
The most abundant inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid (GABA), exerts its main effects via a GABAA receptor that gates a chloride channel in the subsynaptic membrane1. These receptors can contain a modulatory unit, the benzodiazepine receptor, through which ligands of different chemical classes can increase or decrease GABAA receptor function2,3. We have now visualized a GABAA receptor in mammalian brain using monoclonal antibodies. The protein complex… Expand
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  • 58
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  • 169
  • Highly Influenced
  • PDF
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References

SHOWING 1-10 OF 18 REFERENCES
Radiohistochemical localization of benzodiazepine receptors in rat brain.
  • W. Young, M. Kuhar
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1980
  • 364
Benzodiazepine receptor protein identified and visualized in brain tissue by a photoaffinity label.
  • 247
  • PDF
Molecular heterogeneity of benzodiazepine receptors
  • 308
A gamma-aminobutyric acid/benzodiazepine receptor complex of bovine cerebral cortex.
  • 326
...
1
2
...