Co-involvement of the mitochondria and endoplasmic reticulum in cell death induced by the novel ertargeted protein HAP

@article{Xu2006CoinvolvementOT,
  title={Co-involvement of the mitochondria and endoplasmic reticulum in cell death induced by the novel ertargeted protein HAP},
  author={Hua Xu and Quan Spring Zhou and Xin Liu and Yi-peng Qi},
  journal={Cellular & Molecular Biology Letters},
  year={2006},
  volume={11},
  pages={249-255}
}
HAP (a homologue of the ASY/Nogo-B protein), a novel human apoptosis-inducing protein, was found to be identical to RTN3. In an earlier study, we demonstrated that HAP localized exclusively to the endoplasmic reticulum (ER) and that its overexpression could induce cell apoptosis via a depletion of endoplasmic reticulum (ER) Ca2+ stores. In this study, we show that overexpression of HAP causes the activation of caspase-12 and caspase-3. We still detected the collapse of mitochondrial membrane… CONTINUE READING
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