Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML

  title={Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML},
  author={Andrew C Volk and Jing Li and Junping Xin and Dewen You and Jun Zhang and Xinli Liu and Yechen Xiao and Peter Breslin and Zejuan Li and Wei Ya Wei and Rachel Schmidt and Xingyu Li and Zhou Zhang and P. C. Kuo and Sucha Nand and Jianke Zhang and Jianjun Chen and Jiwang Zhang},
  booktitle={The Journal of experimental medicine},
Leukemic stem cells (LSCs) isolated from acute myeloid leukemia (AML) patients are more sensitive to nuclear factor κB (NF-κB) inhibition-induced cell death when compared with hematopoietic stem and progenitor cells (HSPCs) in in vitro culture. However, inadequate anti-leukemic activity of NF-κB inhibition in vivo suggests the presence of additional survival/proliferative signals that can compensate for NF-κB inhibition. AML subtypes M3, M4, and M5 cells produce endogenous tumor necrosis factor… CONTINUE READING
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