Co-inheritance of hemoglobin D and β-thalassemia traits in three Iranian families: clinical relevance.

@article{Basmanj2011CoinheritanceOH,
  title={Co-inheritance of hemoglobin D and β-thalassemia traits in three Iranian families: clinical relevance.},
  author={Maryam Taghavi Basmanj and Morteza Karimipoor and Azam Amirian and Masoumeh Jafarinejad and Leila Katouzian and Atefeh Valaei and Fatemeh Bayat and Alireza R Kordafshari and S Zeinali},
  journal={Archives of Iranian medicine},
  year={2011},
  volume={14 1},
  pages={61-3}
}
Here we report the result of three cases referred to our lab that had a combination of β-thalassemia and hemoglobin D (Hb D) traits. These individuals had no symptoms of profound anemia and hematological indices were similar to that of a β-thalassemia heterozygote. In all three cases, the Hb D level was elevated and no HbA was detected electrophoretically. The electrophoresis pattern suggested that all cases were homozygotes for Hb D. PCR followed by digestion with EcoRI and sequencing of the… CONTINUE READING