Co-induction of HSP70 and heme oxygenase-1 in macrophages and glia after spinal cord contusion in the rat.

  title={Co-induction of HSP70 and heme oxygenase-1 in macrophages and glia after spinal cord contusion in the rat.},
  author={Angelika E. M. Mautes and Linda J. Noble},
  journal={Brain research},
  volume={883 2},
HSP70 and heme oxygenase-1 (HO-1) are thought to be markers of cell injury and oxidative stress, respectively. We have immunolocalized these proteins in the spinal cord at 1-14 days after contusion. HSP70 and HO-1 were co-induced in glia and macrophages within the injured segment at all time points. This co-induction may reflect complementary functions that serve to protect these cells as they respond to the postcontusional environment. 

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