Co-induction of CYP3A12 and 3A26 in dog liver slices by xenobiotics: species difference between human and dog CYP3A induction.

@article{Chen2009CoinductionOC,
  title={Co-induction of CYP3A12 and 3A26 in dog liver slices by xenobiotics: species difference between human and dog CYP3A induction.},
  author={Juejing Chen and Cindy H Tran and Li Xiao and Jairam R. Palamanda and Thomas Klapmuts and Pramila Kumari and Xinjie Lin and Er-jia Wang and Yi-Zhong Gu and M. J. Humphries and Annette S. Uss and K-C Cheng},
  journal={Drug metabolism letters},
  year={2009},
  volume={3 1},
  pages={
          61-6
        }
}
The induction of dog CYP3A12 and CYP3A26 mRNA levels was evaluated in liver slices after treatment with 22 xenobiotics. Eleven of the 22 xenobiotics increased 3A12 mRNA by more than four-fold, while nine did the same for 3A26 mRNA. A four-fold increase in the mRNA level was used as the cut-off for indication of induction based on the noise level of the real time-PCR. A good correlation was found between the mRNA levels for 3A12 and 3A26 after treatment with compounds, suggesting that these two… CONTINUE READING