Co-immobilization of Palm and DNase I for the development of an effective anti-infective coating for catheter surfaces.

@article{Alves2016CoimmobilizationOP,
  title={Co-immobilization of Palm and DNase I for the development of an effective anti-infective coating for catheter surfaces.},
  author={Diana Filipa Barros Alves and Andr{\'e}ia Fernandes Magalh{\~a}es and Daria Grzywacz and Damian Neubauer and Wojciech Kamysz and Maria Ol{\'i}via Pereira},
  journal={Acta biomaterialia},
  year={2016},
  volume={44},
  pages={
          313-22
        }
}
UNLABELLED Biomaterial-associated infections, in particular, catheter-associated infections (CAI) are a major problem in clinical practice due to their ability to resist antimicrobial treatment and the host immune system. This study aimed to co-immobilize the antimicrobial lipopeptide Palm and the enzyme DNase I to introduce both antimicrobial and anti-adhesive functionalities to polydimethylsiloxane (PDMS) material, using dopamine chemistry. Surface characterization confirmed the… CONTINUE READING
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