Co-expression of urotensin II and its receptor (GPR14) in human cardiovascular and renal tissues.

@article{Matsushita2001CoexpressionOU,
  title={Co-expression of urotensin II and its receptor (GPR14) in human cardiovascular and renal tissues.},
  author={Masahiro Matsushita and Masayoshi Shichiri and Toshio Imai and Masatora Iwashina and Hideaki Tanaka and Nobuyuki Takasu and Yasunobu Hirata},
  journal={Journal of hypertension},
  year={2001},
  volume={19 12},
  pages={2185-90}
}
BACKGROUND Urotensin-II (UII), a cyclic dodecapeptide originally isolated from fish urophysis that has potent cardiovascular effects, has recently been identified as an endogenous ligand for the orphan G protein-coupled receptor, GPR14. The physiological roles of endogenous UII and its receptor in humans remain unknown. OBJECTIVE To investigate the presence of human (h) UII-like immunoreactivity (hUII-LI) in human biological fluids, and the expression of hUII and GPR14 genes in human tissues… CONTINUE READING
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