Co-expression of tissue inhibitor and matrix metalloproteinase in myocardium.

  title={Co-expression of tissue inhibitor and matrix metalloproteinase in myocardium.},
  author={Suresh C Tyagi and Sushanth Kumar and John Banks and Wilbert Fortson},
  journal={Journal of molecular and cellular cardiology},
  volume={27 10},
Matrix metalloproteinases (MMP) are present in the latent form in normal myocardium. To examine the stringent balance between MMP and tissue inhibitor of metalloproteinase (TIMP) and to determine whether MMP are secreted simultaneously and in co-ordination with their inhibitors, we analysed MMP and TIMP by immunological, isolation by gel-permeation and affinity chromatography, and enzymatic assays in tissues and extracts. Using antibodies to MMP-1 and TIMP-1, we found strong in situ staining of… CONTINUE READING


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