Co-expression of IGF-1 family members with myogenic regulatory factors following acute damaging muscle-lengthening contractions in humans.

@article{McKay2008CoexpressionOI,
  title={Co-expression of IGF-1 family members with myogenic regulatory factors following acute damaging muscle-lengthening contractions in humans.},
  author={Bryon R. McKay and Ciara E. O'Reilly and Stuart M Phillips and Mark A Tarnopolsky and Gianni Parise},
  journal={The Journal of physiology},
  year={2008},
  volume={586 22},
  pages={5549-60}
}
Muscle regeneration following injury is dependent on the ability of muscle satellite cells to activate, proliferate and fuse with damaged fibres. This process is controlled by the myogenic regulatory factors (MRF). Little is known about the temporal relation of the MRF with the expression of known myogenic growth factors (i.e. IGF-1) in humans following muscle damage. Eight subjects (20.6 +/- 2.1 years; 81.4 +/- 9.8 kg) performed 300 lengthening contractions (180 deg s(-1)) of their knee… CONTINUE READING