Co-exposure to cigarette smoke and alcohol decreases airway epithelial cell cilia beating in a protein kinase Cε-dependent manner.

@article{Wyatt2012CoexposureTC,
  title={Co-exposure to cigarette smoke and alcohol decreases airway epithelial cell cilia beating in a protein kinase Cε-dependent manner.},
  author={Todd A Wyatt and Joseph H. Sisson and Diane Allen-Gipson and Michael L. McCaskill and Jessica A Boten and Jane M Devasure and Kristina L. Bailey and Jill A. Poole},
  journal={The American journal of pathology},
  year={2012},
  volume={181 2},
  pages={431-40}
}
Alcohol use disorders are associated with increased lung infections and exacerbations of chronic lung diseases. Whereas the effects of cigarette smoke are well recognized, the interplay of smoke and alcohol in modulating lung diseases is not clear. Because innate lung defense is mechanically maintained by airway cilia action and protein kinase C (PKC)-activating agents slow ciliary beat frequency (CBF), we hypothesized that the combination of smoke and alcohol would decrease CBF in a PKC… CONTINUE READING

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